Association between VEGF-634G/C polymorphism and susceptibility to autoimmune diseases: A meta-analysis

作者：Chen Haikui; Zhang Tianyun; Gong Bolin; Cao Xiaohong^*

来源：Gene, 2015, 558(2): 181-186.

DOI：10.1016/j.gene.2015.01.023

• VEGF-634G/C
• Polymorphism
• Autoimmune diseases
• Meta-analysis

The role of VEGF - 634G/C polymorphism has been involved in the investigations of susceptibility to autoimmune diseases, but the conclusion remains controversial. Here, we have performed a meta-analysis to clarify the relationship between them. All relevant articles updating to August 2013 were searched in PubMed and EMBASE. Crude odds ratios (ORs) with 95% confidence intervals (CIs) based on the available articles were calculated. A total of 24 independent studies associated with autoimmune disease were analyzed in our research. The results show that VEGF 634G/C polymorphism was associated with susceptibility to autoimmune disease in Asian population (C vs. G: OR = 0.88, 95% Cl: 0.80-0.96, P = 0.543; CC vs. GG: OR = 0.77,95% Cl: 0.63-0.93, P = 0.787; CC + GC vs. GG: OR = 0.80, 95% CI: 0.67-0.96, P = 0.080 by random effects model). Nevertheless, no significant associations were found in total population or in other stratified groups. In the current meta-analysis, we reveal a significant association between VEGF 634G/C polymorphism and susceptibility to autoimmune diseases in Asian population.

• 出版日期2015-3-10
• 单位宁夏大学; 北方民族大学