Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis

作者：Mas Nuket; Tasci Ilker; Comert Bilgin; Ocal Ramazan; Mas Mehmet Refik^*

来源：World Journal of Gastroenterology, 2008, 14(7): 1108-1111.

DOI：10.3748/wjg.14.1108

• rat liver fibrosis
• rat liver cirrhosis
• ursodeoxycholic acid
• electron microscopy
• hepatocyte ultrastructure

AIM: To examine the ultrastructural changes after ursodeoxycholic acid (UDCA) treatment in hepatocytes from experimentally induced fibrotic livers.
METHODS: Liver fibrosis was induced in male Sprague-Dawley rats with CCl4 for 12 wk, and the rats were divided into two groups. Group I was treated with saline and group H with UDCA (25 mg/kg per day) for 4 wk. All the rats were killed at wk 16. Mitochondria, nuclei, rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) of hepatocytes were evaluated according to a scoring system.
RESULTS: Mitochondria, nuclei, RER and SER injury scores in group II were significantly lower than those in group I (P < 0.001).
CONCLUSION: UDCA alleviates hepatocyte organelle injury in CCl4-induced liver fibrosis.

• 出版日期2008-2-21
• 单位中国人民解放军军事医学科学院