A facile synthesis of lipo-chitopentaose nodulation factor

作者：Huang G L^*; Wong Kongliang

来源：Letters in Organic Chemistry, 2007, 4(8): 588-589.

DOI：10.2174/157017807782795475

• lipo-chitopentaose nodulation factor
• chemo-enzymatic synthesis
• degradation velocity
• chitinase

We prepared the penta-N-acetyl-chitopentaose 2 by using recombinant Escherichia coli ( E. coli) strains harboring the nodC gene ( encoding chitooligosaccharide synthase) from Azorhizobium caulinodans. The deacetylase NodB removed the N-acetyl moiety from the nonreducing terminus of 2 to give tetra-N-acetyl-chitopentaose 3. N-Acylation of 3 with stearyl chloride was performed in DMF containing water and provided the corresponding lipo-chitopentaose nodulation factor 4.

• 出版日期2007
• 单位重庆师范大学