Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology

作者：Yoo Byoung Kwon; Emdad Luni; Lee Seok Geun; Su Zao zhong; Santhekadur Prasanna; Chen Dong; Gredler Rachel; Fisher Paul B; Sarkar Devanand^*

来源：Pharmacology & Therapeutics, 2011, 130(1): 1-8.

DOI：10.1016/j.pharmthera.2011.01.008

• Astrocyte elevated gene-1 (AEG-1)
• Oncogene
• Metastasis
• Chemoresistance
• Angiogenesis
• Neurodegeneration

Since its initial identification and cloning in 2002, Astrocyte Elevated Gene-1 (AEG-1), also known as metadherin (MTDH), 3D3 and LYsine-RIch CEACAM1 co-isolated (LYRIC), has emerged as an important oncogene that is overexpressed in all cancers analyzed so far. Examination of a large cohort of patient samples representing diverse cancer indications has revealed progressive increase in AEG-1 expression with stages and grade; of the disease and an inverse relationship between AEG-1 expression level and patient prognosis. AEG-1 functions as a bona fide oncogene by promoting transformation. In addition, it plays a significant role in invasion, metastasis, angiogenesis and chemoresistance, all important hallmarks of an aggressive cancer. AEG-1 is also implicated in diverse physiological and pathological processes, such as development, inflammation, neurodegeneration, migraine and Huntington's disease. AEG-1 is a highly basic protein with a transmembrane domain and multiple nuclear localization signals and it is present in the cell membrane, cytoplasm, nucleus, nucleolus and endoplasmic reticulum. In each location, AEG-1 interacts with specific proteins thereby modulating diverse intracellular processes the combination of which contributes to its pleiotrophic properties. The present review provides a snapshot of the current literature along with future perspectives on this unique molecule.

• 出版日期2011-4