Nickel-Catalyzed C(sp3)-H Arylation of Diarylmethane Derivatives with Aryl Fluorides

作者：Li, Jie^*; Wu, Chen; Zhou, Bihui; Walsh, Patrick J.^*

来源：Journal of Organic Chemistry, 2018, 83(5): 2993-2999.

DOI：10.1021/acs.joc.8b00016

• C-F BOND
• CROSS-COUPLING PROCESSES
• NICKEL/MAGNESIUM BIMETALLIC COOPERATION
• ALKYL GRIGNARD-REAGENTS
• ORGANOZINC REAGENTS
• ROOM-TEMPERATURE
• ALPHA-ARYLATION
• EFFICIENT SYNTHESIS
• PROCESSES DCCP
• H BONDS

A novel nickel-catalyzed C(sp(3))-H arylation with nonactivated aryl fluorides is reported. The use of 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene (IMes) as a ligand was found to be critical to the success of the reaction. This new method enables the synthesis of a wide range of triarylmethane derivatives.

• 出版日期2018-3-2
• 单位浙江大学城市学院