MR prediction of liver fibrosis using a liver-specific contrast agent: Superparamagnetic iron oxide versus Gd-EOB-DTPA

作者：Nishie Akihiro^*; Asayama Yoshiki; Ishigami Kousei; Tajima Tsuyoshi; Kakihara Daisuke; Nakayama Tomohiro; Takayama Yukihisa; Okamoto Daisuke; Taketomi Akinobu; Shirabe Ken; Fujita Nobuhiro; Obara Makoto; Yoshimitsu Kengo; Honda Hiroshi

来源：Journal of Magnetic Resonance Imaging, 2012, 36(3): 664-671.

DOI：10.1002/jmri.23691

• MRI
• superparamagnetic iron oxide
• T2*
• map
• Gd-EOB-DTPA
• liver cirrhosis

Purpose: To examine whether the uptake of a liver-specific contrast agent in the liver parenchyma was correlated with the degree of liver fibrosis. Materials and Methods: This retrospective study included 54 and 63 patients who underwent superparamagnetic iron oxide (SPIO)- and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI before liver surgery, respectively. For each patient, we calculated ?R2* and ?R2, which represent differences in R2* and R2 values of the liver parenchyma before and after administration of SPIO; and the increase rate of liver-to-spleen signal intensity ratio (LSR) on the hepatobiliary phase compared with the precontrast image. The correlation of each MR parameter with the degree of liver fibrosis (F0 to F4) was assessed using Spearman%26apos;s rank correlation test. Results: The increase rate of LSR was best correlated with the degree of liver fibrosis and significantly decreased as the liver fibrosis progressed (rho = -0.641; P %26lt; 0.0001). It showed sensitivity of 76.9% and specificity of 83.3% in differentiating F3 or greater fibrosis when 1.126 or less was set up as a cut-off value. No significant correlation was obtained between ?R2* or ?R2 and the degree of liver fibrosis. Conclusion: The uptake of Gd-EOB-DTPA in the liver parenchyma decreased as the liver fibrosis progressed. J. Magn. Reson. Imaging 2012;36:664671.

• 出版日期2012-9