alpha-Metallated O-2-Alkenyl Carbamates: Synthetic Equivalents of Chiral Homoenolates and Materials for Asymmetric Homoaldol Reaction

作者：Hoppe Dieter^*

来源：Synthesis (Germany), 2009, 2009(1): 43-55.

DOI：10.1055/s-0028-1083280

• asymmetric synthesis
• homoenolates
• stereoselective deprotonation
• chiral carbanions
• (-)-sparteine

The review article provides a personal overview on the development and application in enantioselective synthesis of nonracemic chiral homoenolate reagents, based on allylic N,N-dialkylcarbamates and the ideas behind it. Further, the impact of these results, concerning stereoselective deprotonation, mainly under the influence of the chiral diamine (-)-sparteine, for the generation of a wide range of chiral building blocks is briefly presented.

• 出版日期2009-1-2