Association between allergies, asthma, and breast cancer risk among women in Ontario, Canada

作者：Lowcock Elizabeth C^*; Cotterchio Michelle; Ahmad Noor

来源：Cancer Causes & Control, 2013, 24(5): 1053-1056.

DOI：10.1007/s10552-013-0177-1

• Breast cancer
• Allergy
• Asthma
• Case-control

To investigate the association between allergies, asthma, and breast cancer risk in a large, population-based case-control study.
Breast cancer cases (n = 3,101) were identified using the Ontario Cancer Registry and population controls (n = 3,471) through random digit dialing. Self-reported histories of allergies, hay fever, and asthma were collected by questionnaire. Logistic regression was used to assess associations between breast cancer risk and history of allergy/hay fever and asthma, with 16 possible confounders examined. Analyses were stratified by menopausal status.
A history of allergies or hay fever was associated with a small reduction in breast cancer risk [age-adjusted odds ratio (AOR) = 0.86, 95 % confidence interval (CI) 0.77-0.96] and did not differ by menopausal status. Asthma was not associated with breast cancer risk overall; however, among premenopausal women, asthma was associated with a reduced risk of breast cancer (AOR = 0.72, 95 % CI 0.54-0.97).
A history of allergies may be associated with a modest reduction in breast cancer risk. Asthma does not appear to be associated with breast cancer risk overall; however, asthma may be associated with reduced breast cancer risk among premenopausal women.

• 出版日期2013-5