Use of Xylitol To Enhance the Therapeutic Efficacy of Polymethylmethacrylate-Based Antibiotic Therapy in Treatment of Chronic Osteomyelitis

作者：Beenken Karen E; Bradney Laura; Bellamy William; Skinner Robert A; McLaren Sandra G; Gruenwald M Johannes; Spencer Horace J; Smith James K; Haggard Warren O; Smeltzer Mark S^*

来源：Antimicrobial Agents and Chemotherapy, 2012, 56(11): 5839-5844.

DOI：10.1128/AAC.01127-12

Using a rabbit model of postsurgical osteomyelitis, we demonstrate that incorporation of xylitol into polymethylmethacrylate (PMMA) bone cement enhances the elution of daptomycin under in vivo conditions. We also demonstrate that this can be correlated with an improved therapeutic outcome in the treatment of a chronic bone infection following surgical debridement.

• 出版日期2012-11