Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules

作者：Focken Thilo; Hanessian Stephen^*

来源：Beilstein Journal of Organic Chemistry, 2014, 10: 1848-1877.

DOI：10.3762/bjoc.10.195

• conjugate addition
• cyclopropanation
• olefination
• organophosphorus
• phosphonamide
• total synthesis

A review of the synthesis of natural products and bioactive compounds adopting phosphonamide anion technology is presented highlighting the utility of phosphonamide reagents in stereocontrolled bond-forming reactions. Methodologies utilizing phosphonamide anions in asymmetric alkylations, Michael additions, olefinations, and cyclopropanations will be summarized, as well as an overview of the synthesis of the employed phosphonamide reagents.

• 出版日期2014-8-13