Arbidol: a quarter-century after. Past, present and future of the original Russian antiviral

作者:Balakin Konstantin V; Filosa Rosanna; Lavrenov Sergey N; Mkrtchyan Arthur S; Nawrozkij Maxim B; Novakov Ivan A
来源:Russian Chemical Reviews, 2018, 87(6): 509-552.
DOI:10.1070/RCR4791

摘要

The present review is concerned with the synthesis and structure - activity relationship studies of Arbidol and its structural analogues. The latter are roughly divided into several unequal parts: indole- and benzofuran-based compounds, benzimidazole and imidazopyridine bioisosteres and ring-expanded quinoline derivatives. Much attention is focused on various types of antiviral activity of the above-mentioned Arbidol congeners, as well as of the parent compound itself. Features of Arbidol synthesis and metabolic changes are also discussed. The bibliography includes 166 references.

  • 出版日期2018