Sec-translocase mediated membrane protein biogenesis

作者：Dalbey RE^*; Chen MY

来源：Biochimica et Biophysica Acta-Molecular Cell Research, 2004, 1694(1-3): 37-53.

DOI：10.1016/j.bbamcr.2004.03.009

• SecYEG
• membrane protein insertions membrane protein assembly
• protein targeting
• membrane translocation

a-Helical transmembrane proteins in bacteria are localized within the plasma membrane. The membrane assembly of these proteins requires protein devices for insertion into the lipid bilayer. In E. coli, membrane proteins require the SRP pathway components Ffh. 4.5S RNA and FtsY for membrane targeting and the SecYEGDF translocase and. in some cases. SecA. for translocation of hydrophilic domains. In addition, YidC, a recently discovered membrane protein, mediates the membrane integration and folding of hydrophobic domains of membrane proteins. In this review, we will describe the current status of the protein targeting and membrane integration pathways.

• 出版日期2004-11-11