Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

作者：Makela Kari Matti^*; Traylor Matthew; Oksala Niku; Kleber Marcus E; Seppala Ilkka; Lyytikainen Leo Pekka; Hernesniemi Jussi A; Kahonen Mika; Bevan Steve; Rothwell Peter M; Sudlow Cathie; Dichgans Martin; Delgado Graciela; Grammer Tanja B; Scharnagl Hubert; Markus Hugh S; Maerz Winfried; Lehtimaki Terho

来源：Atherosclerosis, 2014, 234(1): 214-217.

DOI：10.1016/j.atherosclerosis.2014.03.002

• Oxidized low-density lipoprotein
• Stroke
• Transient ischaemic attack
• Genetics
• Single nucleotide polymorphism

Background and purpose: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). %26lt;br%26gt;Methods: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A; N=2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B; N 3548 cases, 5972 controls). %26lt;br%26gt;Results: In study A, the prevalence of hypertension, diabetes and %26gt; 50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p=0.030; odds ratio=1.29 [95% confidence interval 1.03-1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke. %26lt;br%26gt;Conclusions: The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.

• 出版日期2014-5
• 单位河北医科大学