Anti-abortion and Fertility Vaccine Potential of Defined Double Deletion (Delta aroA Delta htrA) Mutant (S30) of Salmonella Abortusequi in Equids

作者：Chandra Mudit^*; Singh Bhoj Raj; Babu Nagaiajan; Agarwal Ravi Kant; Siddiqui Mahtab Z

来源：Journal of Equine Veterinary Science, 2014, 34(6): 765-773.

DOI：10.1016/j.jevs.2014.01.010

• Oral vaccine
• Equine
• Salmonella Abortusequi
• Deletion mutant

The present study on defined double deletion (Delta aroA Delta htrA) mutant (S30) of Salmonella enterica serovar Abortusequi evaluated it for safety, immunogenicity, and efficacy as a vaccine candidate in equids. The candidate strain was found safe in equids (foals, male and female horses and donkeys, and pregnant and nonpregnant mares) and induced good humoral and cell-mediated immunity on administration through oral route. The strain was not excreted in feces of vaccinated animals. The vaccine candidate administered orally (1 x 10(11) cfu per animal) protected mares even after 180 days of inoculation against abortion on challenge with wild-type S. Abortusequi strain whereas in nonvaccinated control, all mares aborted. The vaccination in infertile mares resulted in regaining of fertility in 67%-80% thoroughbred mares at two different breeding farms. Further, the humoral immunity was transferred to foals from vaccinated mothers through colostrum, but no placental transfer was evident. Thus, the vaccine under study may be recommended for use in equids to control S. Abortusequi infection-associated abortions and also to enhance fertility of temporarily infertile mares in endemic areas.

• 出版日期2014-6