Mouse DNA polymerase iota lacking the forty-two amino acids encoded by exon-2 is catalytically inactive in vitro

作者：Frank Ekaterina G; McDonald John P; Yang Wei; Woodgate Roger

来源：DNA Repair, 2017, 50: 71-76.

DOI：10.1016/j.dnarep.2016.12.004

• 129-derived strains of mice
• DNA polymerase ι
• Mutagenesis
• Translesion DNA synthesis
• Y-family DNA polymerase

In 2003, we reported that 129-derived strains of mice carry a naturally occurring nonsense mutation at codon 27 of the Poli gene that would produce a polι peptide of just 26 amino acids, rather then the full-length 717 amino acid wild-type polymerase. In support of the genomic analysis, no polι prot...

• 出版日期2017-2
• 单位National Institutes of Health