A CRISPR View of Cleavage

作者：Weinberger Ariel D^*; Gilmore Michael S

来源：Cell, 2015, 161(5): 964-966.

DOI：10.1016/j.cell.2015.05.003

Seminal studies showed that CRISPR-Cas systems provide adaptive immunity in prokaryotes and promising gene-editing tools from bacteria to humans. Yet, reports diverged on whether some CRISPR systems naturally target DNA or RNA. Here, Samai and colleagues unify the studies, showing that a single type III CRISPR-Cas system cleaves both DNA and RNA targets, independently.

• 出版日期2015-5-21