Dopamine-deficiency-enhanced hyperthermia and rhabdomyolysis during a heat wave in a metachromatic leucodystrophy heterozygote with metabolic myopathy

作者：Finsterer Josef^*; Reining Festa Alice; Stollbergr Claudia; Voigtlander Till

来源：Acta Neurologica Belgica, 2011, 111(4): 321-324.

• Heat wave
• hyperthermia
• hyperpyrexia
• dopamine-deficiency
• metabolic myopathy
• hyper-CK-emia
• leucodystrophy
• heterozygote

Whether a dopamine-deficiency syndrome in a Parkinson-syndrome (PS) may occur more easily during a heat wave than during more temperate climate conditions is unknown. We report a case that may suggest this.
A 56 yo male with heterozygosity for metachromatic leucodystrophy and a history of metabolic myopathy, PS and diabetes experienced worsening of the PS during a heat wave. His condition further deteriorated upon reduction of ropinirol, resulting in hyperthermia, respiratory insufficiency, rhabdomyolysis, and severe thrombocytopenia. One month later he was alert but tetraplegic and required ventilatory support. Hyper-CK-emia returned to similar levels as before rhabdomyolysis.
Reduction of dopamine agonists during a heat wave may induce a dopamine deficiency syndrome with hyperthermia, rhabdomyolysis and thrombocytopenia.

• 出版日期2011-12