ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65

作者：Li, Jing-kun; Cheng, Lei; Zhao, Yun-peng; Guo, Ying-jun; Liu, Yi; Zhang, Wei; Wang, Shuai-shuai; Zhang, Yuan-qiang; Pan, Xin^*; Nie, Lin

来源：Mediators of Inflammation, 2015, 2015: 196702.

DOI：10.1155/2015/196702

• OLIGOMERIC MATRIX PROTEIN
• AVASCULAR NECROSIS
• RHEUMATOID-ARTHRITIS
• EARLY-DIAGNOSIS
• GROWTH-FACTOR
• HIP-JOINT
• IN-VITRO
• OSTEOARTHRITIS
• BONE
• METALLOPROTEINASE

ADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF-alpha and NF-kappa B signaling pathway. In this study we compared the expression of ADAMTS-7, TNF-alpha, and Phospho-NF-kappa B in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS-7, TNF-alpha, and Phospho-NF-kappa B was significantly upregulated in ONFH patients' articular cartilage and related to the pathogenesis of ONFH. Thus we conclude that ADAMTS-7 level appears to be positively associated with expression of TNF-alpha and Phospho-NF-kappa B P65 in cartilage, which may imply its association with cartilage destruction of ONFH.

• 出版日期2015
• 单位山东大学