Acute Effects of Dipyrone on Renal Function in Patients with Cirrhosis: A Randomized Controlled Trial

作者：Zapater Pedro^*; Llanos Lucia; Barquero Claudia; Bellot Pablo; Pascual Sonia; Carnicer Fernando; Maria Palazon Jose; Gimenez Paula; Esteban Angel; Llorca Lourdes; Frances Ruben; Francisco Horga Jose; Such Jose

来源：Basic and Clinical Pharmacology and Toxicology, 2015, 116(3): 257-263.

DOI：10.1111/bcpt.12312

Use of non-steroidal anti-inflammatory drugs in cirrhosis has been associated with impairment of renal function based on its ability to inhibit the renal production of prostaglandins. Renal effects of dipyrone in patients with cirrhosis have not been evaluated. We aimed to assess the renal effect of therapeutic doses of dipyrone used for short periods of time in patients with cirrhosis. Twenty-nine patients with cirrhosis were included in an observer-blind clinical trial. Patients were randomized to receive three times a day oral acetaminophen (500mg; N=15) or dipyrone (575mg; N=14) for 72hr. Serum and urine samples were obtained at baseline, 48 and 72hr, and cystatin C, creatinine, aldosterone, 6-keto-Prostaglandin-F1 alpha and prostaglandin E2 were measured. Cystatin C and creatinine levels remained comparable in patients treated with acetaminophen and dipyrone. Urine and serum prostaglandins concentrations were significantly decreased at 72hr in patients treated with dipyrone regardless of the status of ascites. One patient with ascites treated with dipyrone required a paracentesis and developed renal insufficiency. We conclude that dipyrone and acetaminophen did not reduce renal function when used for short periods of time (up to 72hr) in patients with cirrhosis. However, considering that dipyrone lowered renal vasodilator prostaglandins synthesis, acetaminophen appears as the safest choice with respect to kidney function in cirrhosis.

• 出版日期2015-3