Xeroderma Pigmentosum Complementation Group C Protein (XPC) Expression in Basal Cell Carcinoma

作者：Yang Lien Chuan; Hsiao Yu Ping; Lu Chun Te; Huang Chun Huang; Chao Wan Ru; Lin Yu Ting; Su Hsuan An; Chang Shih Liang; Chung Jing Gung^*

来源：In Vivo, 2015, 29(1): 35-38.

• Xeroderma pigmentosum complementation group C protein (XPC)
• Basal cell carcinoma (BCC)
• skin cancer

Background: The Xeroderma pigmentosum complementation group C protein (XPC) is a general sensor of damaged DNA. Individuals carrying a mutation in XPC genes exhibit marked photosensitivity and increased occurrence of skin cancers. Little is known about the distribution of XPC protein in basal cell carcinoma (BCC). Aim: To determine whether the XPC protein is associated with basal cell carcinoma. Materials and Methods: In the present study, we investigated the protein expression of XPC by immunohistochemistry in 86 cases of BCC and paired-adjacent normal epidermis. Results: The intensity of nuclear XPC expression was significantly higher in BCC compared to adjacent normal epidermis (p<0.001). Attenuated XPC expression was associated with high-risk BCC (p=0.045) but was not significantly associated with age, gender and body area. Conclusion: Our results indicate that XPC is associated with BCC and further studies are warranted to determine if the XPC-BCC interaction is specific to just one cancer cell type and to investigate potential mechanisms.

• 出版日期2015-2
• 单位中国医科大学; 河北医科大学