Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients

作者：Scheithauer Simone^*; Haase Gerhard; Haeusler Martin; Lemmen Sebastian; Ritter Klaus; Kleines Michael

来源：Journal of Cystic Fibrosis, 2010, 9(3): 234-236.

DOI：10.1016/j.jcf.2010.02.002

• Infection
• Exacerbation
• Emerging viruses
• Herpesvirus

Respiratory viruses discovered in the 21st century and human herpes viruses (N=13) were seldom (4/50) detected in our cystic fibrosis patients although exacerbation frequency (7.75 +/- 2.9/a versus 4.45 +/- 2.1/a; p=0.03) and colonization with Aspergillus fumigatus (RR: 2.6; CI95: 1.8-3.7), Pseudomonas aeruginosa (RR: 1.84; CI95: 1.4-2.4), and Staphylococcus aureus (RR: 1.5; CI95: 1.2-1.9) including MRSA (RR: 4.6; CI95: 1.3-16.6) were associated with virus positivity. Further studies should clarify whether this finding reflects non-specific colonization (human Bocavirus) or reactivation (Epstein-Barr virus) or rather an acceleration of lung tissue inflammation.

• 出版日期2010-5