XenoSite server: a web-available site of metabolism prediction tool

作者：Matlock Matthew K; Hughes Tyler B; Swamidass S Joshua^*

来源：Bioinformatics, 2015, 31(7): 1136-1137.

DOI：10.1093/bioinformatics/btu761

A Summary: Cytochrome P450 enzymes (P450s) are metabolic enzymes that process the majority of FDA-approved, small-molecule drugs. Understanding how these enzymes modify molecule structure is key to the development of safe, effective drugs. XenoSite server is an online implementation of the XenoSite, a recently published computational model for P450 metabolism. XenoSite predicts which atomic sites of a molecule-sites of metabolism (SOMs)-are modified by P450s. XenoSite server accepts input in common chemical file formats including SDF and SMILES and provides tools for visualizing the likelihood that each atomic site is a site of metabolism for a variety of important P450s, as well as a flat file download of SOM predictions.

• 出版日期2015-4-1