Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of alpha(1A)-adrenergic receptors

作者：Alcantara Hernandez Rocio; Hernandez Mendez Aurelio; Teresa Romero Avila M; Alfonzo Mendez Marco A; Pupo Andre S; Adolfo Garcia Sainz J

来源：Biochimica et Biophysica Acta-Molecular Cell Research, 2017, 1864(12): 2378-2388.

DOI：10.1016/j.bbamcr.2017.09.002

• Α 1A -Adrenergic receptors
• Oxymetazoline
• Biased agonism
• Desensitization
• Phosphorylation sites
• Mass spectrometry

Abstract(#br)In LNCaP cells that stably express α 1A -adrenergic receptors, oxymetazoline increased intracellular calcium and receptor phosphorylation, however, this agonist was a weak partial agonist, as compared to noradrenaline, for calcium signaling. Interestingly, oxymetazoline-induced receptor...

• 出版日期2017-12