Morphological and mechanical properties of tannic acid/PAAm semi-IPN hydrogels for cell adhesion

作者：Hu, Xinyu^*; Wang, Yongmei; Zhang, Liangliang; Xu, Man

来源：Polymer Testing, 2017, 61: 314-323.

DOI：10.1016/j.polymertesting.2017.05.034

• Tannic acid
• Cryogels
• Macropores
• Cell adhesion
• High elasticity
• Degradation

A series of hydrogels were fabricated from tannic acid (TA), a typical plant polyphenol widely present in wood, and polyacrylamide (PAAm) by semi-IPN and cryogelation techniques. The introduction of TA into the PAAm network endows the system with enhanced cell adhesion properties. The cryogels with open interconnected macropores had a superfast swelling rate and a high swelling ratio, as well as high elasticity in response to compression. The degradation of the hydrogels can be tuned by modulating the content of cross-linker poly(ethylene glycol) diacrylate (PEGDA). Cytotoxicity results revealed that the hydrogels were non-toxic to COS-7 cells. All these results suggested that TA/PAAm semi-IPN hydrogels have great potential for applications in tissue engineering.

• 出版日期2017-8
• 单位中国林业科学研究院林产化学工业研究所