Antiphotoaging effect and purification of an antioxidant peptide from tilapia (Oreochromis niloticus) gelatin peptides

作者：Sun, Liping; Zhang, Yufeng; Zhuang, Yongliang^*

来源：Journal of Functional Foods, 2013, 5(1): 154-162.

DOI：10.1016/j.jff.2012.09.006

• Tilapia gelatin
• Antioxidant
• Photoaging
• Purification
• Amino acid sequence
• Peptide

In this study, the effect of tilapia gelatin peptides (TGP) on UV-induced damages to mice skin was evaluated. The antioxidant indicators, lipid, collagen and glycosaminoglycan of mice skin were determined and histological changes of the collagen were depicted. The results showed TGP could alleviate the UV-induced abnormal changes of antioxidant indicators, and the protective effect was in dose-dependent manners. TGP could protect skin lipid and collagen from the UV radiation damages, and the change of glycosaminoglycan was also recovered significantly. The action mechanisms of TGP mainly involved the antioxidant properties and the repairing to endogenous collagen synthesis. Therefore, the key antioxidant peptide was further purified from TGP. Finally, one antioxidant peptide was identified and the amino acid sequence was Leu-Ser-Gly-Tyr-Gly-Pro (592.26 Da). The IC50 value of this peptide on hydroxyl radical scavenging activity was 22.47 mu g/mL. TGP could be a novel antiphotoaging agent from natural resources.

• 出版日期2013-1
• 单位昆明理工大学