Alternating verbal fluency performance following bilateral subthalamic nucleus deep brain stimulation for Parkinson%26apos;s disease

作者：Marshall D F; Strutt A M; Williams A E; Simpson R K; Jankovic J; York M K^*

来源：European Journal of Neurology, 2012, 19(12): 1525-1531.

DOI：10.1111/j.1468-1331.2012.03759.x

• deep brain stimulation
• neuropsychology
• Parkinson%26apos
• s disease
• verbal fluency

Background and purpose Despite common occurrences of verbal fluency declines following bilateral subthalamic nucleus deep brain stimulation (STN-DBS) for the treatment of Parkinson%26apos;s disease (PD), alternating fluency measures using cued and uncued paradigms have not been evaluated. %26lt;br%26gt;Methods Twenty-three STN-DBS patients were compared with 20 non-surgical PD patients on a comprehensive neuropsychological assessment, including cued and uncued intradimensional (phonemic/phonemic and semantic/semantic) and extradimensional (phonemic/semantic) alternating fluency measures at baseline and 6-month follow-up. %26lt;br%26gt;Results STN-DBS patients demonstrated a greater decline on the cued phonemic/phonemic fluency and the uncued phonemic/semantic fluency tasks compared to the PD patients. For STN-DBS patients, verbal learning and information processing speed accounted for a significant proportion of the variance in declines in alternating phonemic/phonemic and phonemic/semantic fluency scores, respectively, whilst only naming was related to uncued phonemic/semantic performance for the PD patients. Both groups were aided by cueing for the extradimensional task at baseline and follow-up, and the PD patients were also aided by cueing for the phonemic/phonemic task on follow-up. %26lt;br%26gt;Conclusions These findings suggest that changes in alternating fluency are not related to disease progression alone as STN-DBS patients demonstrated greater declines over time than the PD patients, and this change was related to declines in information processing speed.

• 出版日期2012-12