An Overview on Chemistry and Biological Importance of Pyrrolidinone

作者：Hosseinzadeh Zahra; Ramazani Ali; Hosseinzadeh Kamaleddin; Razzaghi Asl Nima; Gouranlou Farideh

来源：Current Organic Synthesis, 2018, 15(2): 166-178.

DOI：10.2174/1570179414666170908165445

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<jats:title>Background: </jats:title>
<jats:p>Pyrrolidinone is a five membered heterocyclic ring that is a versatile lead compound
for designing powerful bioactive agents. Pyrrolidinone nucleus is one of the most important heterocyclic compound
indicating notable pharmaceutical effects. Many procedures for the preparation of pyrrolidinone and
also their various reactions offer great scope in the field of medicinal chemistry. This fascinating group of
compounds has diverse pharmacological activities such as antibacterial, antifungal, anticancer and anticonvulsant.
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<jats:sec>
<jats:title>Objective: </jats:title>
<jats:p> The review article proposes to classify comprehensive information on chemistry and pharmaceutical
effects of pyrrolidinone in order to open new viewpoint for future studies.
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<jats:sec>
<jats:title>Conclusion:</jats:title>
<jats:p> It is clear from the review of the topic that a wide spectrum of pyrrolidinone analogues have been
synthesized and the majority of these derivatives have indicated different significant biological activities. Thus,
these analogues can be used for future progression of novel drugs against many more poor agents.</jats:p>
</jats:sec>

• 出版日期2018