A non-opioid pathway for dynorphin-caused spinal cord injury in rats

作者：Chen, Yu; Xiang, Liangbi^*; Liu, Jun; Zhou, Dapeng; Yu, Hailong; Wang, Qi; Han, Wenfeng; Guo, Mingming

来源：Neural Regeneration Research, 2012, 7(11): 815-820.

DOI：10.3969/j.issn.1673-5374.2012.11.003

• spinal cord injury
• dynorphin
• kappa opioid receptor antagonist
• N-methyl-D-aspartate receptor antagonist
• motor function
• acid phosphatase

Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor.

• 出版日期2012-4-15