Adsorption and transformation of the anthelmintic drug niclosamide by manganese oxide

作者：Thai Ha Tran; Labanowski Jerome; Gallard Herve^*

来源：Chemosphere, 2018, 201: 425-431.

DOI：10.1016/j.chemosphere.2018.03.021

• Niclosamide
• Manganese oxide
• Natural organic matter
• Adsorption
• Oxidation

The manganese oxide birnessite adsorbed and catalyzed the transformation of the anthelminthic drug niclosamide (NIS) into 2-chloro-4-nitroaniline (CNA) and 5-chlorosalicylic acid (CSA) at acidic pH. The adsorption of NIS was fitted using a linear isotherm for all conditions and reaction times. Linear adsorption constant K-d was 103 000 L kg(-1) at pH 5.0. The rate of transformation was first order with respect to both MnO2 and NIS. At pH 5.0, the second order rate constant was 33 (+/- 0.3) x 10(-1)M(-1)s(-1). The adsorption constants and the rates of transformation decreased when pH increased from 4.0 to 5.5 because of increasing electrostatic repulsions between both negatively charged manganese oxide surface (pH(zpc) = 2.5) and NIS (pKa = 638). The presence of natural organic matter (NOM) extracted from surface water also significantly decreased the adsorption and the rates of transformation of NIS. The rate of transformation decreased by a factor of 20 in presence of 1.6 mgC L-1 even though significant amounts of NIS were adsorbed onto MnO2. The interactions between NOM and NIS were investigated by using the fluorescence quenching method and would explain that NIS adsorbed on the surface of manganese oxide was stable in presence of NOM. Thus, hydrolysis catalyzed by manganese oxide is probably not an important process compared to biodegradation and adsorption because of the presence of organic matter and pH values usually > 5.5 in aquatic environment.

• 出版日期2018-6