Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications

作者：Auksorius Egidijus^*; Bromberg Yaron; Motiejuenaite Rueta; Pieretti Alberto; Liu Linbo; Coron Emmanuel; Aranda Jorge; Goldstein Allan M; Bouma Brett E; Kazlauskas Andrius; Tearney Guillermo J

来源：Biomedical Optics Express, 2012, 3(3): 661-666.

DOI：10.1364/BOE.3.000661

Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence microscopy on one platform can increase its versatility since it enables co-localized registration of optically sectioned reflectance and fluorescence images. To demonstrate the potential of this dual modality, a fixed and labeled mouse retina was imaged. Results showed that both techniques can provide complementary information and therefore the system could potentially be useful for biomedical imaging applications.

• 出版日期2012-3-1