科研之友
微信
新浪微博
Facebook
分享链接
摘要
The four component reactions involving diazoamides, amines, aldehydes, exomethylenes/imines were performed in the presence of copper(I) thiophenecarboxylate as a catalyst to afford dispiroindolopyrrolidine/-imidazolidine derivatives in good yield with regio-, chemo- and diastereoselective manner. The structure and stereochemistry of dispiroheterocyclic ring systems were confirmed based on the representative single-crystal X-ray analysis. These reactions involve the generation of intermolecular azomethine ylide intermediates and the subsequent 1,3-dipolar cycloaddition process with olefins or imines.
- 出版日期2016-5-12
