Mismatch Negativity and Ear Laterality in Alzheimer's Disease and in Mild Cognitive Impairment

作者：Idrizbegovic Esma^*; Hederstierna Christina; Rosenhall Ulf

来源：Journal of Alzheimer's Disease, 2016, 53(4): 1405-1410.

DOI：10.3233/JAD-160323

• Central auditory processing disorders
• cortical auditory event-related potentials
• left ear advantage
• right ear advantage
• subjective memory complaints

Background: Cortical auditory event-related potentials (ERPs) were studied in order to measure mismatch negativity (MMN). Three groups of subjects were studied: patients with Alzheimer's disease (AD, n = 32), mild cognitive impairment (MCI, n = 44), and subjective memory complaints without cognitive decline (SMC, n = 27). A bottom up strategy was applied, and the right and left ears were stimulated monaurally.
Objective: To investigate MMN in AD and MCI, and in a clinical reference group.
Methods: ERPs were carried out with 500 tone pulses at 80 dBnHL. Each sequence included 80% standard tones (500 Hz) (f), and 20% deviant tones (1000 Hz) (r). MMN measurements were carried out by comparing the amplitudes of (f) and (r) recordings and to calculate the amplitude difference in mu V for each group. The right and the left ears were analyzed separately.
Results: A left ear advantage (LEA) of MMN amplitude was demonstrated in the two groups with better cognition (the MCI and the SMC groups), but not in the AD group.
Discussion: The absence of MMN asymmetry in the AD group is possibly caused by a dysfunction to apprehend changes of tonal stimuli.

• 出版日期2016