A New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8C(T)

作者：Lee Seoung Rak; Beemelmanns Christine; Tsuma Leah M M; Clardy Jon; Cao Shugeng^*; Kim Ki Hyun^*

来源：Natural Product Communications, 2016, 11(4): 461-463.

DOI：10.1177/1934578x1601100410

• Diketopiperazines
• Cyclo(D-trans-Hyp-L-Leu)
• Structural elucidation
• Marfey's method

Bacterially-produced small molecules demonstrate a wide range of structural and functional diversity. A new diketopiperazine, cyclo(D-trans-Hyp-L-Leu) (1), and five other known diketopiperazines (2-6), were isolated and purified from the fermented broth of a Kenyan bacterium Bacillus licheniformis LB 8C(T). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including 2D NMR and HR-MS, and the absolute configuration was determined by a combination of NOESY analysis and Marfey's method. The known compounds were identified as cyclo(D-cis-Hyp-L-Leu) (2), cyclo(D-cis-Hyp-L-Phe) (3), cyclo(D-Pro-L-Tyr) (4), cyclo-(D-Trp-L-Leu) (5), and cyclo(L-Tyr-Gly) (6) by comparison of their spectroscopic and physical data with reported values. Compounds 1-6 were tested for antifungal and antimicrobial properties.

• 出版日期2016-4