Differential Impacts of Alternative Splicing Networks on Apoptosis

作者：Lin Jung Chun; Tsao Mei Fen; Lin Ying Ju

来源：International Journal of Molecular Sciences, 2016, 17(12): 2097.

DOI：10.3390/ijms17122097

• alternative splicing
• apoptosis
• organogenesis
• carcinogenesis

Apoptosis functions as a common mechanism to eliminate unnecessary or damaged cells during cell renewal and tissue development inmulticellular organisms. More than 200 proteins constitute complex networks involved in apoptotic regulation. Imbalanced expressions of apoptosis-related factors frequently lead to malignant diseases. The biological functions of several apoptotic factors are manipulated through alternative splicing mechanisms which expand gene diversity by generating discrete variants from one messenger RNA precursor. It is widely observed that alternatively-spliced variants encoded from apoptosis-related genes exhibit differential effects on apoptotic regulation. Alternative splicing events are meticulously regulated by the interplay between trans-splicing factors and cis-responsive elements surrounding the regulated exons. The major focus of this review is to highlight recent studies that illustrate the influences of alternative splicing networks on apoptotic regulation which participates in diverse cellular processes and diseases.

• 出版日期2016-12
• 单位中国医科大学