A Nation-Wide Cancer Registry-Based Study of Adenosquamous Carcinoma in Taiwan

作者：Lan Yuan Tzu; Huang Kuo Hung; Liu Chien An; Tai Ling Chen; Chen Ming Huang; Chao Yee; Li Anna Fen Yau; Chiou Shih Hwa; Shyr Yi Ming; Wu Chew Wun; Fang Wen Liang^*

来源：PLos One, 2015, 10(10): e0139748.

DOI：10.1371/journal.pone.0139748

Background
Adenosqamous carcinoma (ASC) is a rare disease involving various organs, yet there are no large-scale population-based comparative studies on ASC among different organs.
Methods
The incidence and overall survival of ASC among various organs in cases diagnosed in Taiwan from January 1, 2003 to December 31, 2010 were calculated and compared using data from the Taiwan Cancer Registry (TCR). The various organs were classified and divided into three different systems: the female reproductive, respiratory, and alimentary systems. Survival analysis were also compared among 30,850 patients diagnosed as ASC, adenocarcinoma (AC) or squamous cell carcinoma (SCC) in organs with frequent ASC.
Results
During the study period, a total of 576 ASC cases were diagnosed in Taiwan. The most common primary system was respiratory (73.8%), followed by alimentary (16.2%) and female reproductive (10%). The overall survival were significantly higher for cases involving the female reproductive system, followed by the respiratory and alimentary systems (P = 0.016). The median overall survival were worse in males than females for cases involving the respiratory system (22.4 vs. 31.8 months, P = 0.044). Multivariate analysis showed that age >= 65, more advanced T and N categories were independent unfavorable prognostic factors of overall survival in ASC. ASC histology is an independent unfavorable prognostic factor compared with AC and SCC.
Conclusions
ASC at an old age and more advanced T and N categories were found to be associated with a poor prognosis.

• 出版日期2015-10-7