The lectin pathway and its implications in coagulation, infections and auto-immunity

作者：Degn Soren E; Jensenius Jens C; Bjerre Mette^*

来源：Current Opinion in Organ Transplantation, 2011, 16(1): 21-27.

DOI：10.1097/MOT.0b013e32834253df

• coagulation
• ficolin
• infection
• lectin pathway
• mannan-binding lectin
• MAP-1
• MAp44

Purpose of review
To give a comprehensive overview of the recently published studies on the role of the lectin pathway in coagulation, infections and auto-immunity.
Recent findings
We present the status quo picture of the lectin pathway, including the newly discovered member, MAp44 (a.k.a. MAP-1), which may act as a specific regulator of activation. On the functional side the focus is on the important discoveries of the connections between the coagulation system and mannose-binding lectin-associated serine proteases, newly discovered associations between the lectin pathway and infectious diseases, especially among neonates, the recent findings of the involvement of mannan-binding lectin and ficolins in auto-immune disorders, and novel therapeutic avenues. The involvement of the lectin pathway in ischemia-reperfusion injuries and transplantations is discussed elsewhere in this issue.
Summary
The emerging picture of the lectin pathway is that it may play a role in the case of concomitant impairments of cellular and adaptive immunity, as seen in the case of premature infants, neonates, neutropenic cancer patients and the like. Considering the near-exponential increase in interest for the lectin pathway and its intricacies in recent years, the future of the field seems promising.

• 出版日期2011-2