Mechanisms of Disease: beta-adrenergic receptors - alterations in signal transduction and pharmacogenomics in heart failure

作者：Feldman DS^*; Carnes CA; Abraham WT; Bristow MR

来源：Nature Clinical Practice Cardiovascular Medicine, 2005, 2(9): 475-483.

DOI：10.1038/ncpcardio0309

• beta-adrenergic receptor
• gene polymorphism
• heart failure
• pharmacogenomics
• signal transduction

beta-adrenergic signaling is an important regulator of myocardial function. During the progression of heart failure (HF), a reproducible series of biochemical events occurs that affects beta-adrenergic receptor (beta-AR) signaling and cardiac function. Furthermore, there are pathophysiologic alterations in the expression and regulation of proteins that are regulated by beta-ARs during HE Analyses of these complex signaling pathways have led to a better understanding of HF mechanisms and the use of beta-adrenergic antagonists, which have notably altered HF-related morbidity and mortality. Despite therapeutic advances that have affected beta-AR signaling, HF remains a leading cause of hospitalization and a principal cause of death in industrialized nations. In this review, we summarize current insights into beta-adrenergic signal-transduction pathways, the best-described beta-AR polymorphisms, and therapies that target the beta-AR pathway in HF.

• 出版日期2005-9