Drug development of herbomineral capsule (ALG-06) used for hypopigmentation specially in vitiligo

作者：Huma Ambreen^*; Rizwani Ghazala H; Usman Muhammed; Ishaque Sumaira; Ansari Shakeel Ahmed; Anwer Sohail

来源：Pakistan Journal of Pharmaceutical Sciences, 2014, 27(5): 1451-1457.

• Hypopigmentation or vitiligo
• physicochemical
• pharmaceutical
• herbomineral capsule

Many herbomineral preparations in traditional medicines are being used from time immemorial like Kushta Abrak Safaid, Busoor-e-Labinyah etc. as therapeutics remedies in common ailments such type of preparations are known to have additive and pronounced effects to cure any obstinate disease condition. The main objective of this research study is the formulation of herbomineral capsule (ALG-06) to treat such type of condition like hypopigmentation in case of vitiligo. In order to achieve the best quality of this formulation physicochemical analysis i.e. fluorescence test, ash values, extractive values and moisture content of combined powdered drug of herbs and minerals were performed followed by phytopharmaceutical calculation of flow ability of blended powder by means of angle of repose, porosity, bulk and tap density, compressibility and hausner ratio, these properties assisted to estimate the best form of powdered material filled in right size of capsule for the desired strength i.e.500mg. Accelerated stability studies were also performed to establish the efficacy of the formulation. In this regard organoleptic properties (color, odor, appearance and taste), weight variation, disintegration and bio burden of ALG-06 formulation were monitored at 40 degrees C/75% relative humidity (RH) along with a room temperature (RT) for a period of one month.

• 出版日期2014-9