Acid-Catalyzed Multicomponent Tandem Cyclizations: Access to Polyfunctional Dihydroindolizino[8,7-b]indoles

作者：Cai, Qun; Li, Deng-Kui; Zhou, Rong-Rong; Shu, Wen-Ming; Wu, Yan-Dong^*; Wu, An-Xin^*

来源：Organic Letters, 2016, 18(6): 1342-1345.

DOI：10.1021/acs.orglett.6b00281

• 1,3-DIPOLAR CYCLOADDITION REACTIONS
• LIGHT PHOTOREDOX CATALYSIS
• CASCADE REACTIONS
• DOMINO REACTIONS
• REGIOSELECTIVE SYNTHESIS
• OXIDATIVE CYCLIZATION
• MOLECULAR BEHAVIORS
• INDOLE ALKALOIDS
• NATURAL-PRODUCTS
• DERIVATIVES

An acid-catalyzed multicomponent tandem cyclization protocol has been developed for the synthesis of polyfunctional dihydroindolizino[8,7-b]indoles from simple and readily available arylglyoxal monohydrates, tryptamines, and trans-beta-nitrostyrenes or malononitrile. This reaction represents a highly efficient and convenient methodology for the synthesis of diversely substituted heteropolycyclic scaffolds under mild, metal-free conditions.

• 出版日期2016-3-18
• 单位华中师范大学