Central Nervous System Manifestations of Systemic Lupus Erythematosus

作者：Jafri Kashif; Patterson Sarah L; Lanata Cristina^*

来源：Rheumatic Disease Clinics of North America, 2017, 43(4): 531-+.

DOI：10.1016/j.rdc.2017.06.003

• Neuropsychiatrie lupus
• Anti-neuronal antibody
• Blood-brain barrier dysfunction

Neuropsychiatric systemic lupus erythematosus (NPSLE) encompasses a variety of phenomena. Manifestations are focal or diffuse, and correlate with disease mechanisms. Recent understanding of the contribution of blood-brain barrier dysfunction to the passage of circulating antineuronal antibodies into the brain parenchyma has shed light on pathogenesis. Correct attribution of neuropsychiatric manifestations to SLE remains a challenge, but validated attribution models will help. Diagnosis relies on characteristic clinical manifestations, SLE disease activity, antibody measurements, cerebrospinal fluid findings, specific neuroimaging findings, and exclusion of alternative causes. Current treatment encompasses the identification and management of the inciting event, symptomatic treatment, and anticoagulation or immunosuppression.

• 出版日期2017-11