Brain-heart communication: Evidence for "central pacemaker" oscillations with a dominant frequency at 0.1 Hz in the cingulum

作者：Pfurtscheller Gert; Schwerdtfeger Andreas R^*; Seither Preisler Annemarie; Brunner Clemens; Aigner Christoph Stefan; Brito Joana; Carmo Marciano P; Andrade Alexandre

来源：Clinical Neurophysiology, 2017, 128(1): 183-193.

DOI：10.1016/j.clinph.2016.10.097

• 0.1-Hz oscillations
• Heart rate variability
• BOLD oscillations
• Central commands
• Central pacemaker
• Resting state

Objectives: In the brain and heart, oscillations at about 0.1 Hz are conspicuous. It is therefore worthwhile to study the interaction between intrinsic BOLD oscillations (0.1 Hz) and slow oscillations in heart rate interval (RRI) signals and differentiate between their neural and vascular origin.
Methods: We studied the phase-coupling with a 3T scanner with high scanning rate between BOLD signals in 22 regions and simultaneously recorded RRI oscillations in 23 individuals in two resting states.
Results: By applying a hierarchical cluster analysis, it was possible to separate two clusters of phasecoupling between slow BOLD and RRI oscillations in the midcingulum, one representative for neural and the other for vascular BOLD oscillations. About half of the participants revealed positive time delays characteristic for neural BOLD oscillations and neurally-driven RRI oscillations.
Conclusions: The results suggest that slow vascular and neural BOLD oscillations can be differentiated and that intrinsic oscillations (0.1 Hz) originate in the cingulum or its close vicinity and contribute to heart rate variability (HRV).
Significance: The study provides new insights into the dynamics of resting state activities, helps to explain HRV, and offers the possibility to investigate slow rhythmic neural activity changes in different brain regions without EEG recording.

• 出版日期2017-1
• 单位河北医科大学