Aerobic radical-cascade cycloaddition of isocyanides, selenium and imidamides: facile access to 1,2,4-selenadiazoles under metal-free conditions

作者：Fang, Yi; Zhu, Zheng-Lin; Xu, Pei; Wang, Shun-Yi; Ji, Shun-Jun^*

来源：Green Chemistry, 2017, 19(7): 1613-1618.

DOI：10.1039/c6gc03521c

• MULTICOMPONENT REACTIONS
• CATALYZED SYNTHESIS
• 1,3-DIPOLAR CYCLOADDITION
• MOLECULAR COMPLEXITY
• EFFICIENT SYNTHESIS
• EBSELEN
• ISONITRILES
• DERIVATIVES
• CHEMISTRY
• INSERTION

A novel and facile metal-free method for the green synthesis of 1,2,4-selenadiazol-5-amine derivatives through the aerobic radical-cascade multi-component reactions of isocyanides, selenium powder and imidamides is reported herein. O-2 in the air was employed as the green oxidant to achieve the cycloaddition with the generation of H2O as the sole by-product. It also features good functional group compatibility and broad substrate scope. In addition, this method was successfully applied to the functionalization of biologically active molecules.

• 出版日期2017-4-7
• 单位苏州大学