A One-Pot, Three-Component Synthesis of 3-(1H-Pyrazol-1-yl)-4H, 7H-[1,2,4,5] tetraazino[6,1-b][1,3] benzoxazin-7-ones under Solvent-Free Conditions

作者：Adib, Mehdi^*; Soheilizad, Mehdi; Zhu, Long-Guan; Wu, Jing

来源：Synlett, 2015, 26(2): 177-182.

DOI：10.1055/s-0034-1378928

• [1,2,4,5] tetraazino[6,1-b][1,3] benzoxazin-7-ones
• 1,2-dihydro-3,6-bis(1H-pyrazol-1-yl)-1,2,4,5-tetrazine
• solvent-free reaction
• multicomponent reactions
• cyclizations
• heterocycles

A one-pot, three-component synthesis of 3-(1H-pyrazol-1yl)- 4H, 7H-[1,2,4,5] tetraazino[6,1-b][1,3] benzoxazin-7-ones is described which involves heating a mixture of 1,2-dihydro-3,6-bis(3,5-dimethyl- 1H-pyrazol-1-yl)-1,2,4,5-tetrazine, aldehydes, and dimedone in the presence of a catalytic amount of p-toluenesulfonic acid under solvent-free conditions. The bridgehead-fused 6: 6: 6 systems with one ring-junction nitrogen atom were obtained in excellent yields.

• 出版日期2015-1
• 单位浙江大学