科研之友
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摘要
Objective-To determine the efficacy and safety of topical administration of selamectin and to compare selamectin treatment with a common ivermectin protocol for the treatment of natural infestation with Trixacarus caviae in pet guinea pigs. %26lt;br%26gt;Design-Clinical trial. %26lt;br%26gt;Animals-17 mixed-breed pet guinea pigs with active mite infestation. %26lt;br%26gt;Procedures-Guinea pigs were randomly allocated to receive a single dose of selamectin topically (15 mg/kg [6.8 mg/lb]) or ivermectin (400 mu g/kg [181.8 mu g/lb], SC) every 10 days for 4 injections. Microscopic examination of skin scrapings from all animals was performed at 10-day intervals for 60 days, and the presence of mites or mite eggs was recorded. The efficacies of the 2 treatment protocols were compared at every time point. %26lt;br%26gt;Results-Pruritus resolved by day 10 in all animals. Animals were microscopically mite-free on days 30 and 40 in the selamectin and ivermectin treatment groups, respectively, but groups did not differ significantly in regard to the number of mite-positive animals at any timepoint. Recurrence of infection was not noted in either treatment group. No adverse reactions were observed in any of the treated animals. %26lt;br%26gt;Conclusions and Clinical Relevance-Results suggested that a single topical application of selamectin at a dose of 15 mg/kg or repeated SC injection of ivermectin at a dose of 400 mu g/kg can eliminate T caviae mites from guinea pigs within 30 and 40 days, respectively. Although effectiveness did not significantly differ between the 2 treatments, the convenience associated with the single topical dose of selamectin made it a preferable treatment modality for both patients and owners. (J Am Vet Med Assoc 2012;241:1056-1058)
- 出版日期2012-10-15
