Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis

作者：Ono Masafumi^*; Ochi Tsunehiro; Munekage Kensuke; Ogasawara Mitsunari; Hirose Akira; Nozaki Yasuko; Takahashi Masaya; Okamoto Nobuto; Saibara Toshiji

来源：Hepatology Research, 2011, 41(12): 1223-1229.

DOI：10.1111/j.1872-034X.2011.00883.x

• angiotensinogen gene haplotype
• non-alcoholic steatohepatitis
• single-nucleotide polymorphisms

Aim: Non-alcoholic steatohepatitis (NASH) patients frequently have hypertension, which is considered to be an important predictive factor for the subsequent development of hepatic fibrosis. The renin-angiotensin system is also known to contribute to the progression of NASH. Various types of functional single-nucleotide polymorphisms (SNPs) involved in the development of NASH have been proposed. Angiotensinogen (AGT) gene SNPs related to cardiovascular diseases have been reported. We aimed to evaluate the involvement of the AGT gene haplotype in Japanese NASH patients.

• 出版日期2011-12