Attractive natural products with strained cyclopropane and/or cyclobutane ring systems

作者：Fan, Yao-Yue; Gao, Xin-Hua; Yue, Jian-Min^*

来源：Science China Chemistry, 2016, 59(9): 1126-1141.

DOI：10.1007/s11426-016-0233-1

• natural products
• cyclopropane-containing
• cyclobutane-containing
• biological activity
• biosynthetic pathway

The strained cyclopropane and/or cyclobutane subunits occurred in many complex natural products including terpenoids, steroids and alkaloids. Natural products with cyclopropane and/or cyclobutane motifs not only furnished fascinating structures, but also exhibited versatile biological activities, such as cytotoxic, anti-HIV, antimicrobial, antiviral, and immunosuppressive effects. This review covered a large array of structurally unique natural products with strained cyclopropane and/or cyclobutane motifs and summarized their structural features, distributions, biological activities, as well as biogenetic considerations.

• 出版日期2016-9
• 单位中国科学院上海药物研究所