科研之友
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摘要
BackgroundAs the science of breast reconstruction evolves, significant changes in reconstruction strategies and outcomes are expected. The purpose of this study is to determine the changes in breast reconstruction trends and outcomes that occurred at a multidisciplinary academic institution during the last decade. MethodsWe compared 265 patients over two distinct 6-month intervals separated by 5 years (2002 vs. 2007) and performed long-term follow-up (4.753.38 years 2002, 2.992.25 years 2007). We studied patients seeking prophylactic mastectomy, patients with early breast cancer, and patients with locally advanced disease. We analyzed demographic data, breast cancer history and treatment, type and timing of reconstruction, and complications. ResultsImplant to flap reconstruction ratio was 48:49 in 2002 and 76:102 in 2007. Use of transverse rectus abdominis myocutaneous flap declined from 57 to 4%; conversely, deep inferior epigastric perforator flap increased from 27 to 91% (P<0.001). Correspondingly, donor site chronic pain (4 vs. 0, P=0.012) and postoperative abdominal wall bulge (9 vs. 3, P=0.004) rates decreased. Timing of reconstruction showed increased staged cases in 2007 compared to 2002 (P=0.045). Post-final reconstruction radiation therapy was reduced in 2007 (P=0.016), with subsequent lower rates of implant rupture (P<0.001). ConclusionsAt our institution and over the last decade, increasing staged reconstructions have successfully reduced the rates of post-final reconstruction radiotherapy with optimized outcomes. Contrary to national trends, the rates of autologous flap reconstructions have increased with reduced donor site morbidity. This suggests that academic breast reconstruction trends are independent from national trends.
- 出版日期2014-11
