科研之友
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摘要
We report an organocatalytic addition of nitromethane to aryl -ketoester-derived N-tosyl ketimines or isatin-derived N-tert-butyloxycarbonyl ketimines, catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene (1-5mol%). Initial screenings reveal that the reaction with a quinine-derived bifunctional catalyst, which features a C6 phenolic hydroxy group, achieved up to 71% ee.
- 出版日期2014-4
- 单位华东师范大学
