Association of angiotensin-converting enzyme I/D and alpha-actinin-3 R577X genotypes with metabolic syndrome risk factors in Korean children

作者：Kim Kijin^*; Ahn Nayoung; Park Jusik; Koh Jinho; Jung Suryun; Kim Sanghyun; Moon Sangbok

来源：Obesity Research & Clinical Practice, 2016, 10: S125-S132.

DOI：10.1016/j.orcp.2015.09.008

• ACE gene I/D
• ACTN3 gene R577X
• Metabolic risk factors
• Children

Objective: This study analysed the risk factors associated with metabolic syndrome through the interaction between ACTN3 and ACE gene polymorphism in Korean children.
Methods: The subjects of the study consisted of elementary school students (n = 788, age 10.10 +/- 0.07 yr). The anthropometric parameters, blood lipid profiles, and metabolic markers were compared among groups of the ACE I/D or the ACTN3 R577X polymorphisms.
Results: The subjects with the DD genotype showed significantly higher systolic blood pressure than the subjects with the II and ID genotype of the ACE gene polymorphism. XX genotype had significantly lower waist-hip ratio than those with RR genotype of the ACTN3 gene polymorphism. Also, the subjects with XX genotype exhibited significantly higher blood HDL cholesterol level than those with RR or RX genotype. The interaction of ACTN3 and ACE gene polymorphism in subjects having both ACE DD and ACTN3 RR genotypes demonstrated a significantly higher metabolic syndrome score than any other groups.
Conclusion: The children having both ACTN3 RR or RX genotype and ACE DD genotype showed high systolic blood pressure and low blood HDL cholesterol level, which may be considered a high-risk in metabolic syndrome.

• 出版日期2016-9