A Variant in LIN288 Is Associated with 2D:4D Finger-Length Ratio, a Putative Retrospective Biomarker of Prenatal Testosterone Exposure

作者：Medland Sarah E; Zayats Tetyana; Glaser Beate; Nyholt Dale R; Gordon Scott D; Wright Margaret J; Montgomery Grant W; Campbell Megan J; Henders Anjali K; Timpson Nicholas J; Peltonen Leena; Wolke Dieter; Ring Susan M; Deloukas Panos; Martin Nicholas G; Smith George Davey; Evans David M^*

来源：American Journal of Human Genetics, 2010, 86(4): 519-525.

DOI：10.1016/j.ajhg.2010.02.017

The ratio of the lengths of an individual's second to fourth digit (2D:4D) is commonly used as a noninvasive retrospective biomarker for prenatal androgen exposure. In order to identify the genetic determinants of 20:40, we applied a genome-wide association approach to 1507 11-year-old children from the Avon Longitudinal Study of Parents and Children (ALSPAC) in whom 2D:4D ratio had been measured, as well as a sample of 1382 12- to 16-year-olds from the Brisbane Adolescent Twin Study. A meta-analysis of the two scans identified a single variant in the LIN28B gene that was strongly associated with 2D:4D (rs314277: p = 4.1 x 10(-8)) and was subsequently independently replicated in an additional 3659 children from the ALSPAC cohort (p = 1.53 x 10(-6)). The minor allele of the rs314277 variant has previously been linked to increased height and delayed age at menarche, but in our study it was associated with increased 20:4D in the direction opposite to that of previous reports on the correlation between 2D:4D and age at menarche. Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure.

• 出版日期2010-4-9
• 单位河北医科大学